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Enzyme Engineering Scientist at ZymoChem

San Leandro, CA, US

The Opportunity

The Enzyme Engineering Scientist will join our rapidly growing R&D team and spearhead the Enzyme Development Group for the fast-paced, high-throughput development of superior enzymes associated with the company’s de novo-designed carbon conserving metabolic pathways. This role is a career-defining opportunity to gain experience and skills with hiring & managing a small team along with creating and implementing ZymoChem’s protein engineering pipeline with state-of-the-art techniques and tools. The Enzyme Engineering Scientist will also be a critical part of multi-disciplinary collaborations with other ZymoChem groups as well as the company’s external partners to accelerate enzyme engineering efforts and expand the company’s IP portfolio.

 

Responsibilities

  • Lead multiple enzyme engineering projects in parallel, both internally as well as with ZymoChem collaborators

  • Develop in vitro and/or in vivo assays for various classes of enzymes

  • Build out the automation capabilities for high-throughput enzyme production and enzyme screening

  • Utilize state-of-the-art computational tools to enable desired enzyme engineering outcomes

  • Establish a data management system to track experimental outputs as well as implement statistical and computational analyses on large data sets

  • Collaborate with the Strain Engineering, Fermentation, and Analytics Groups toward more in-depth characterization of superior enzyme candidates in the leading production strains

 

Qualifications

  • PhD in (Bio)chemistry, Bioengineering, Biophysics, Molecular Biology, or a related discipline working directly on topics related to enzyme characterization or engineering

  • 2+ years of industrial/startup experience working directly on enzyme engineering efforts – particularly with proven results – is strongly preferred

  • Highly proficient with designing and implementing in vitro and in vivo systems for protein production and enzyme activity assays

  • Diverse knowledge base of both wet lab and computational tools (e.g., DNA-to-phenotype relationships) for delivering improved enzymes

  • Experience with molecular modeling and visualization tools such as Rosetta and PyMol, along with scripting tools (e.g., Python, R, MatLab) for analyses of large datasets

  • Hands-on expertises using automation to accelerate enzyme screening workflows

  • Scientific rigor toward continuous evaluation of experimental design, noise/variability, reproducibility, and outcomes

ZymoChem offers full-time employees a competitive base salary and benefits package, and the company is an equal opportunity employer. If this position aligns with your career aspirations, please apply using the form below.