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Job Title: Scientist


		Avila Therapeutics 100 Beaver Street Waltham 02453 www.avilatx.com

	Avila Therapeutics™ is pioneering a method to generate and develop new medicines that achieve ‘protein silencing’ based on the proprietary Avilomics™ platform. These medicines, called covalent drugs, strongly and resiliently bond to disease-causing proteins, resulting in therapies that are highly effective against a broad spectrum of human diseases. The covalent bonding mechanism of Avila’s drugs has the unique property of effectively ‘silencing’ disease-causing proteins by establishing a strong and enduring ‘bond’ – exceeding the more temporary ‘binding’ of conventional drugs – to completely shut down the activity of and silence a disease-causing protein. Avila’s covalent drugs have exceptional therapeutic benefits because they are highly targeted, are effective against mutations and have a long duration of action.

Job Description:

Avila Therapeutics is seeking a qualified Scientist to join the Molecular and Cellular Biology group. The successful candidate will play a lead role in advancing one or more programs by performing mechanism-of-action studies and investigating molecular signaling pathways downstream of drug-target interaction using a variety of in vitro/ex vivo techniques. In addition, the candidate will be instrumental in the development and execution of cell-based assays to characterize the activity of small molecules for the treatment of cancer, viral infections and/or inflammation. Experience in the aforementioned disease areas is highly desirable. In addition, expertise with some or all of the following techniques is essential:

Specific Responsibilities:

● Basic protein characterization involving SDS-PAGE, affinity capture, and established enzyme assays
● Characterization of protein expression by Western blot analysis
● ELISAs to measure proteins, cytokines and tissue-specific markers in tissue culture supernatants, biological fluids and tissues
● Perform assays on various targets to evaluate new chemical compounds
● Cell culture, in vitro and cell-based functional assays
● Cell proliferation assays with primary cells and established cell lines
● Quantitative RT-PCR
● Construction of bacterial and eukaryotic expression vectors
● Transient and stable transfection of established mammalian cell lines

Qualifications:

● Ph.D or equivalent with 0-5 years pharmaceutical/biotech research experience
● Experience with a broad range of molecular biology and cell biology techniques • Ability to work independently to develop and execute cell-based assays
● Experience with small molecule evaluation using protein-protein interactions or cell based functional assays
● Experience with fluorescence microscopy and/or flow cytometry desired

Based in Waltham, MA, Avila Therapeutics is a privately held, early-stage company that is well-financed and uses proprietary methods to discover and develop a novel class of small molecule therapeutics for the treatment of cancer, viral and inflammatory diseases. Avila Therapeutics offers a very competitive benefits program and the opportunity to be part of a dynamic team!

Job Location(s):

Waltham,MA,US

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